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Results The meta-analysis comprised 16 studies and 5,997 patients

Important safety information includes a boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) and warnings for pancreatitis, gallbladder disease, acute kidney injury, and hypoglycemia risk when used with insulin or sulfonylureas

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Thats why careful experiments spread doses across at least three orders of magnitude to find the sweet spot, which moves based on the copper-to-peptide ratio, the buffer used, and how much serum sits in the media